Treatment

Tumor Regression

Tumor-free Survival Total

Median Days to 2 Doublings

Growth Delay (T-C)a

Median T/C (%) Day 26

Compound

Dose mg/kg

Number of Partial

Number of Complete

Duration Med/Range (Days)

Controlb

0

0/10

9.4

DOXb

8

0

9

9/10

>13

>3.6

0

DOX

5.3

0

10

34.3 28 - 48

1/10

67

57.6

0

DOX

3.5

2

7

23.6 1 - 34

1/10

54

45.0

10

DOX-Ob

9.75

2

4

4/10

>13

>3.6

6

DOX-O

6.5

2

8

28.9 11 - 42

1/10

58.7

49.3

8

DOX-O

4.3

1

3

9.3 2 - 25

1/10

41.2

31.8

14